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The oral NMDA receptor positive allosteric modulator zelquistinel (AGN-241751, GATE-251) [100] was investigated in a phase 1/2 trial (NCT03726658) and a phase 2 trial (NCT03586427) for the treatment of MDD, but the studies did not meet their primary efficacy endpoints

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Environment plays a big part in triggering the condition (see below) however one of the key causes is the abnormal functioning of the immune system which leads to inflammation within the skin

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But GSH showed no significant difference in T test